Shai Hills Resource Reserve is a resource reserve located in Doryumu in the Shai Osudoku District all in the Greater Accra Region. It was established in 1962 with area of 47 square kilometres (4,700 ha; 18 sq mi) which was later extended to 47 square kilometres (4,700 ha; 18 sq mi) in 1973 
The area was declared Forest Reserve in 1962 with total area of 47 square kilometres (4,700 ha; 18 sq mi) which was later expanded to 51 square kilometres (5,100 ha; 20 sq mi) in 1973 till present. It was made a Game Production Reserve in 1971. The protected area was home to the Shai people before they were ejected by the British in 1892, remains of Shai peoples works can still be found at the reserve.
Shai Hills Resource Reserve is located along the Tema–Akosombo road. It is about 17 kilometres (11 mi) from Accra, the capital city of Ghana making it the closest wildlife reserve to Accra